For Aprilia, 2001 was a strange season. In the Superbike Championships, the opening and closing races dominated. Corser achieved pole position at Valencia, with Laconi second, marking up two decisive wins. At Imola, the same starting grid, but this time it was Laconi who won the second heat. In between, a series of strange races and the clear impression that the motorbike could have brought home a final result much better than the absolute fourth of Corser and the eleventh of Laconi.

In the SBK, Aprilia totted up three victories, three superpoles, four fastest laps and eight podium places.

Also an inconclusive year in the motorcycle GP. In the 250 cc class, Harada is vice champion, behind the Katoh-Honda duo, Melandri is third, Rolfo fourth, Nieto fifth and McWilliams sixth. Aprilia won 10 pole positions (eight Harada, due Nieto) and five victories (three Harada, one McWilliams and one Melandri), but the effectiveness and continuity of Katoh got the better.

In the 125 cc, the Aprilia presence was maintained by private teams and brought two victories (Cecchinello in Catalonia, Sanna in Germany), 7 podium places, 3 pole positions and four fastest laps.

Lucio Cecchinello came fourth in the world championship classification, Borsoi sixth and Sanna seventh.